GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7226229 | 1 | rs4985953 | chr17:20897584 | USP22 | chr17:20902908-20947073:- | -0.17 | -3.69 | 0.000251 | Blood trace element (Se levels) |
| THCA | cis | rs7226229 | 1 | rs4985954 | chr17:20897952 | USP22 | chr17:20902908-20947073:- | -0.17 | -3.69 | 0.000255 | Blood trace element (Se levels) |
| THCA | cis | rs7226229 | 1 | rs4985955 | chr17:20898014 | USP22 | chr17:20902908-20947073:- | 0.18 | 3.73 | 0.000215 | Blood trace element (Se levels) |
| THCA | cis | rs7226229 | 1 | rs4985962 | chr17:20916035 | USP22 | chr17:20902908-20947073:- | -0.18 | -3.79 | 0.000171 | Blood trace element (Se levels) |
| THCA | cis | rs1834481 | 1 | rs4988359 | chr11:112025915 | BCO2 | chr11:112046208-112095421:+ | 0.23 | 4.59 | 5.61E-6 | Interleukin-18 levels |
| THCA | cis | rs1834481 | 1 | rs4988359 | chr11:112025915 | IL18 | chr11:112013976-112034840:- | -0.24 | -4.51 | 8.25E-6 | Interleukin-18 levels |
| THCA | cis | rs498872 | 1 | rs498872 | chr11:118477367 | IFT46 | chr11:118415259-118436750:- | -0.17 | -3.78 | 0.000178 | Glioma |
| THCA | cis | rs498872 | 1 | rs498872 | chr11:118477367 | TREH | chr11:118528942-118550381:- | 0.3 | 5.34 | 1.44E-7 | Glioma |
| THCA | cis | rs12216499 | 1 | rs4990365 | chr6:159375553 | RSPH3 | chr6:159398268-159421198:- | 0.28 | 6 | 3.97E-9 | Bladder cancer (smoking interaction) |
| THCA | cis | rs7403037 | 1 | rs4992989 | chr15:24821481 | PWRN1 | chr15:24778839-24832924:+ | 0.44 | 9.05 | 3.74E-18 | Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid) |
| THCA | cis | rs2382817 | 1 | rs4996257 | chr2:219162836 | TMBIM1 | chr2:219138917-219157280:- | 0.16 | 3.67 | 0.000272 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| THCA | cis | rs683250 | 1 | rs500059 | chr11:83283859 | CCDC90B | chr11:82972506-82997414:- | -0.15 | -3.65 | 0.000289 | Subcortical brain region volumes |
| THCA | cis | rs683250 | 1 | rs500571 | chr11:83305542 | CCDC90B | chr11:82972506-82997414:- | 0.16 | 3.71 | 0.000235 | Subcortical brain region volumes |
| THCA | cis | rs7226229 | 1 | rs5005801 | chr17:20944154 | USP22 | chr17:20902908-20947073:- | -0.18 | -3.83 | 0.000146 | Blood trace element (Se levels) |
| THCA | cis | rs7769051 | 1 | rs5006218 | chr6:133126220 | C6orf192 | chr6:133090507-133119747:- | -0.24 | -4 | 7.46E-5 | Type 2 diabetes nephropathy |